University of Guilan Journal of Mathematical Modeling 2345-394X 14 2 2026 05 01 Dual analysis of myocardial infarction using fractional mathematical modeling and machine learning 699 722 9299 10.22124/jmm.2025.31534.2837 EN Tharmalingam Gunasekar Department of Mathematics, Vel Tech Rangarajan Dr. Sagunthala R\&D Institute of Science and Technology, Chennai - 600062, Tamil Nadu, India Sumaiya Banu Department of Mathematics, Vel Tech Rangarajan Dr. Sagunthala R\&D Institute of Science and Technology, Chennai - 600062, Tamil Nadu, India Shyam Sundar Santra JIS College of Engineering, Kalyani, Nadia, West Bengal Dumitru Baleanu Department of Computer Science and Mathematics, Lebanese American University, Beirut - 11022801, Lebanon Journal Article 2025 08 30 This paper presents a novel fractional-order mathematical model of myocardial infarction in women who are users of combined oral contraceptive pill and who also develop comorbidity due to various reasons. The system of equations incorporate Caputo fractional derivative to capture memory effects of the model. Existence and uniqueness of solution of the mathematical model is derived. Numerical simulations were rigorously conducted on the math model with varying fractional order namely, $0.3$, $0.5$ and $0.8$ using Euler's method. The numerical results thus obtained are simulated by Adam's method for 200 days period. The output from these simulations form the dataset of the Bayesian regularization neural network (BRNN) with dataset split for training, testing and validatating the computational model. Bayesian regularization is incorporated to handle overfitting efficiently. Root Mean Square Error (RMSE) are computed for all three fractional orders respectively. Regression analysis is conducted which yielded perfect correlation \((R=1)\) accross the all datasets. The combined mathematical and computational analysis form a strong layout in myocardial infarction risk prediction, diagnosis and treatment in young women. Myocardial Infarction Fractional Mathematical Modeling Caputo derivative Combined Oral Contraceptive Pill Bayesian Regularization Neural Network https://jmm.guilan.ac.ir/article_9299_6593aeb65997ccb0968e730a257ed0b3.pdf